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When remains are found amid the rubble after a house fire, authorities soon discover the incident was no accident.

A romantic Mediterranean cruise intended to rekindle the love between a woman and her ex-husband leads to her vanishing; the investigation reveals secret recordings, a surprising star witness and an undercover hit man.

The murder of a young businessman in Old San Juan, Puerto Rico, marks the start of a 15-year-long hunt to find the killer.

A 40-year-old Minnesota woman is shot to death in her bed while her husband and teenage daughter are home, leaving investigators to wonder who would want her dead.

The battle between a wife and a mistress for one man's heart leads to a deadly car chase.

Former DEA agent Andrew Hogan details his search for Mexican drug lord Joaquín "El Chapo" Guzmán with never-before-seen videos and photographs.

Friends think something isn't right after the mysterious disappearance of a Colorado rancher and spend years fighting for answers.

When remains are found amid the rubble after a house fire, authorities soon discover the incident was no accident.

When Tina Sandoval disappears, her parents and loved ones spend years searching for her; a secret she was keeping may lead to clues about what happened to her.

A California woman's two former husbands are mysteriously murdered, nearly 20 years apart.

A woman is found murdered after her close friend hears her screaming on the phone; the mysterious death of her boyfriend's twin brother leads investigators to a suspect.

A nurse is gunned down in her home and detectives believe they have a clear suspect; as they delve deeper into the investigation new information leads them down a completely different path.

After a young father is found dead in his home in Jonesboro, Ark., the authorities search for the killer.

After Tahereh Ghassemi disappears from the Louisiana home she shares with her adult son, detectives discover that she'd recently come into a great deal of money; the investigation reveals an astonishing plot with international implications.

After police discover the burned body of a missing Miami man at the edge of the Florida Everglades, the wife of a local supermarket mogul comes forward to reveal a shocking secret and possible lead.

When a California nursing student disappears during her hospital shift, her family works to locate her.

When two women call 911 after hearing someone break into their apartment, their call for help holds the key to solving the mysterious murder of a young graduate student named Katie Sepich.

When a young woman is found nearly murdered in her apartment, officials wonder if it is connected to the disappearance of a young woman in nearby Denver weeks earlier.

The deadly 2020 shooting at U.S. District Court Judge Esther Salas' home, which killed her son and critically injured her husband.

The murder of a wealthy hotel heir ignites a feud between his wife and stepdaughter.

A soon-to-be bride is caught in the middle of a twisted murder plot that has detectives questioning if she played a role in it.

Two young girls in Washington are snatched in broad daylight while riding their bikes; the case goes unsolved for decades, until a new detective with a local connection to the story tries to solve the mystery.